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Figure 1 | BMC Cell Biology

Figure 1

From: An initial biochemical and cell biological characterization of the mammalian homologue of a central plant developmental switch, COP1

Figure 1

The general characteristics of the mammalian COP1 proteins and genes. (A) Predicted amino acid sequence of HsCOP1. The N-terminal glycine-serine rich extension is underlined. The RING finger domain is boxed. The coiled-coil domain is indicated by dotted lines. The WD40 repeats are double underlined by solid lines and dashed lines. The sequence data were deposited in GenBank/EMBL/DDBJ under the accession number AF508940. (B) The genomic structure of the HsCOP1 gene. The HsCOP1 gene is located on chromosome 1 at position 1q24+1 based on the ideogram. Exons, represented by boxes with the exon numbers indicated above, are distributed over a solid line representing introns, according to proportion. The length of the HsCOP1 gene is indicated above the gene structure diagram. The corresponding sequenced human genomic BAC clones, represented by solid lines, are aligned under the HsCOP1 gene diagram. The HsCOP1 genomic sequence data are available in the Third Party Annotation Section of the DDBJ/EMBL/GenBank databases under the accession number TPA: BK000438. (C) A phylogenetic tree of COP1 proteins from representative species of both animal and plant kingdoms. The phylogenetic tree is constructed by ClustalW software [57], using protein sequences corresponding to the first 200 amino acids of HsCOP1. The protein sequence of HsCOP1 (human) is available under GenBank accession number AF508940. The protein sequence of MmCOP1 (mouse) is available under GenBank accession number AF151110. The partial protein sequence of XlCOP1 (xenopus) was predicted from four xenopus EST clones (GenBank accession number BE506274, BE679680, BE026293 and BG345699). The partial protein sequence of GgCOP1 (chicken) was predicted from one chicken EST clone (GenBank accession number BM487594). The partial protein sequence of DrCOP1 (zebrafish) was predicted from one EST clone (GenBank accession number AI959013). The partial protein sequence of FrCOP1 (fugu) was predicted from scaffold 5023 of the draft fugu genomic sequence. The protein sequence of AgCOP1 (mosquito) was predicted from the scaffold CRA_x9P1GAV59LQ of the draft mosquito genomic sequence. The protein sequences of AtCOP1 (Arabidopsis), PsCOP1 (pea), LeCOP1 (tomato), InCOP1 (morning glory), and OsCOP1 (rice) are available under GenBank accession number L24437, Y09579, AF029984, AF315714, AB040053, respectively.

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