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Figure 3 | BMC Cell Biology

Figure 3

From: A dominant negative mutant of TLK1 causes chromosome missegregation and aneuploidy in normal breast epithelial cells

Figure 3

Overexpression of TLK1B-KD results in missegregation of chromosomes and other mitotic abnormalities. a. A normal metaphase in MM3MG-KD cells. b. Multi-polar spindles frequently found in MM3MG-TLK1B-KD cells. c. Unequal segregation of chromosomes in MM3MG-TLK1B-KD cells. d. Persistence of microtubules from the mitotic spindle after metaphase. e. Persistence of microtubules after cytokinesis found frequently in MM3MG-TLK1B-KD cells. f. A representative metaphase chromosome spread with 84 chromosomes from an MM3MG-TLK1B-KD cell.

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