Normal distribution of the phosphorylated RNA pol II in fibroblast nuclei of AD-EDMD patient 99-3. Fibroblast culture cells from control (a) or patient (b) were immunolabelled with mab V/22 recognizing RNA pol II (a",b"). Note the normal distribution of RNA pol II all over the nucleus in control as well as in patient fibroblasts (compare a" and b"). The corresponding phase-contrast images (a,b) and Hoechst fluorescences (a',b') are shown. Bar: 10 µm.