Figure 5From: Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor β signalingAMSH-2 RNA interference has a negative effect on TGF-β signaling pathway. HepG2 cells were transfected with 3TP-lux reporter and scramble, laminA/C, AMSH-2 or Smad7 siRNA duplexes as indicated in the bottom of the graph. Forty-eight hours posttransfection cells were serum-starved and left treated (black bars) or not (white bars) with 5 ng/ml TGF-β1.Back to article page