Figure 7
From: The XMAP215-family protein DdCP224 is required for cortical interactions of microtubules
Model for the collapse of radial interphase microtubule arrays by disruption of cortical dynein/dynactin function. (A) Cortical dynein/dynactin in cooperation with DdCP224 provides the pulling force for maintenance of radial microtubule arrays. (B) Collapse of the radial microtubule array and altered centrosome positioning due to disruption of most cortical dynein/dynactin complexes and asymmetric pulling forces provided by only a few remaining functional cortical dynein/dynactin complexes (shown in red). This pathway may also involve further proteins which are not depicted in this model.