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Figure 4 | BMC Cell Biology

Figure 4

From: Mutations in the IGF-II pathway that confer resistance to lytic reovirus infection

Figure 4

Alternatively spliced product contains a single nucleotide polymorphism in the igf2 coding sequence. Intron sequences incorporated into the alternatively spliced transcript (highlighted in black) alter the translational reading frame of the pro-homone downstream of the coding sequence of the processed IGF-II protein (italics and bold). The Igf2svPCR product also contained a G to A base substitution (underlined) that replaces alanine with threonine at codon 62 (boxed) of the mature hormone.

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