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Figure 3 | BMC Cell Biology

Figure 3

From: Control and maintenance of mammalian cell size

Figure 3

Hypothetical model of Conlon and Raff where constant size increase independent of cell size allows return of deviant cell sizes to a constant cell size over time (This figure is drawn directly from Conlon and Raff (Conlon and Raff, 2003)). The assumption made for this figure is that both large and small cells increase their mass equally over time. Thus, a cell of size 10 and a cell of size 1 increase their mass over one doubling time by 11 units (the sum of the starting masses, 10 and 1). To the large and small cell an increase of 5.5 units of mass is proposed to occur as cells grow. Thus, the large cell grows to size 15.5 and the small cell grows to size 6.5, and at division the daughter cells now have sizes of 7.75 and 3.25 respectively. This continues for a number of generations as the founder cells, originally of disparate sizes, now converge to the same size.

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