Two Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activities

Table 3 Comparison of Drosophila SOCS.

	Socs36E	Socs44A
Expression-Embryogenesis	Matches known pattern of JAK activation, including pair-rule stripes, gut, and tracheal pits	Distinct from JAK activation, with possible exception of trachea very late
Expression- Oogenesis	Matches known pattern of JAK activation, with graded expression highest at anterior and posterior poles	Distinct from JAK activation, with expression only in nurse cells
Requirement for expression	Requires JAK signaling for embryonic expression	Does not require JAK signaling for embryonic expression
Inducibility	Inducible by JAK activity in embryos	Not inducible by JAK activity in embryos
Regulation of JAK activity	Can repress JAK signaling in wing and possibly in follicle cells of ovary	Can repress JAK signaling in wing, but cannot in follicle cells
Regulation of EGFR activity	Can repress EGFR signaling in wing and possibly in follicle cells of ovary	Can enhance EGFR signaling in wing

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