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Table 3 Comparison of Drosophila SOCS.

From: Two Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activities

  Socs36E Socs44A
Expression-Embryogenesis Matches known pattern of JAK activation, including pair-rule stripes, gut, and tracheal pits Distinct from JAK activation, with possible exception of trachea very late
Expression- Oogenesis Matches known pattern of JAK activation, with graded expression highest at anterior and posterior poles Distinct from JAK activation, with expression only in nurse cells
Requirement for expression Requires JAK signaling for embryonic expression Does not require JAK signaling for embryonic expression
Inducibility Inducible by JAK activity in embryos Not inducible by JAK activity in embryos
Regulation of JAK activity Can repress JAK signaling in wing and possibly in follicle cells of ovary Can repress JAK signaling in wing, but cannot in follicle cells
Regulation of EGFR activity Can repress EGFR signaling in wing and possibly in follicle cells of ovary Can enhance EGFR signaling in wing
  1. The contrasting properties of Socs36E and Socs44A are summarized.