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Expression-Embryogenesis
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Matches known pattern of JAK activation, including pair-rule stripes, gut, and tracheal pits
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Distinct from JAK activation, with possible exception of trachea very late
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Expression- Oogenesis
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Matches known pattern of JAK activation, with graded expression highest at anterior and posterior poles
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Distinct from JAK activation, with expression only in nurse cells
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Requirement for expression
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Requires JAK signaling for embryonic expression
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Does not require JAK signaling for embryonic expression
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Inducibility
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Inducible by JAK activity in embryos
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Not inducible by JAK activity in embryos
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Regulation of JAK activity
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Can repress JAK signaling in wing and possibly in follicle cells of ovary
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Can repress JAK signaling in wing, but cannot in follicle cells
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Regulation of EGFR activity
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Can repress EGFR signaling in wing and possibly in follicle cells of ovary
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Can enhance EGFR signaling in wing
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