Parameter | PE | FN |
---|
cAMP production | ↑ | ↑ |
Protein synthesis | ↑ | ↓ |
DNA synthesis | ↓ | ↓ |
Morphology | enlarged; spindle-shaped | shrunk; rounded |
Differentiation markers | ↑ | ↓ |
Cdk inhibitors | ↑ | ↑ |
- The arrows indicate a significant increase or decrease elicited by PE or FN in the corresponding cell parameter studied. These agents' stimulated cAMP production, decreased basal DNA synthesis, and up-regulated cyclin-dependent kinase inhibitors. PE and cAMP have opposite effects on protein synthesis, cell morphology and smooth muscle differentiation markers.