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Table 3 Comparison of the effects of PE and FN on different cell parameters.

From: Activation of α1A-adrenergic receptor promotes differentiation of rat-1 fibroblasts to a smooth muscle-like phenotype

Parameter

PE

FN

cAMP production

Protein synthesis

DNA synthesis

Morphology

enlarged; spindle-shaped

shrunk; rounded

Differentiation markers

Cdk inhibitors

  1. The arrows indicate a significant increase or decrease elicited by PE or FN in the corresponding cell parameter studied. These agents' stimulated cAMP production, decreased basal DNA synthesis, and up-regulated cyclin-dependent kinase inhibitors. PE and cAMP have opposite effects on protein synthesis, cell morphology and smooth muscle differentiation markers.