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Figure 4 | BMC Cell Biology

Figure 4

From: Dermal fibroblasts in Hutchinson-Gilford progeria syndrome with the lamin A G608G mutation have dysmorphic nuclei and are hypersensitive to heat stress

Figure 4

Ultrastructural analysis of the nuclear envelope in fibroblasts from the subject with HGPS. Low magnification transmission electron microscopic image of a passage 10 PT001 nucleus showed several herniations (a). Two higher-magnification images of the same nucleus at sites of blebs (b and c) showed a close apposition of the chromatin to the nuclear envelope. In a, b, and c the nucleus is to the left. Scale bars correspond to 2 μm in panel a, and 500 nm in panels b and c.

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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