TY - JOUR AU - Oliveira, Roxane AU - Christov, Christo AU - Guillamo, Jean Sébastien AU - de Boüard, Sophie AU - Palfi, Stéphane AU - Venance, Laurent AU - Tardy, Marcienne AU - Peschanski, Marc PY - 2005 DA - 2005/02/16 TI - Contribution of gap junctional communication between tumor cells and astroglia to the invasion of the brain parenchyma by human glioblastomas JO - BMC Cell Biology SP - 7 VL - 6 IS - 1 AB - Gliomas are "intraparenchymally metastatic" tumors, invading the brain in a non-destructive way that suggests cooperation between glioma cells and their environment. Recent studies using an engineered rodent C6 tumor cell line have pointed to mechanisms of invasion that involved gap junctional communication (GJC), with connexin 43 as a substrate. We explored whether this concept may have clinical relevance by analyzing the participation of GJC in human glioblastoma invasion. SN - 1471-2121 UR - https://doi.org/10.1186/1471-2121-6-7 DO - 10.1186/1471-2121-6-7 ID - Oliveira2005 ER -