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Table 1 Cx43 expression and invasive capacity of gliomas maintained in nude mice

From: Contribution of gap junctional communication between tumor cells and astroglia to the invasion of the brain parenchyma by human glioblastomas

    Controls CBX
Tumor Tumor§ Cx43 (S-S0)/S0 Cells/mm perimeter (S-S0)/S0 Cells/mm perimeter
T1 TG-4-GEN +++ 1.15 ± 0.23 77 ± 9.4 1.05 ± 0.11 68 ± 5.6
T2 TG-1-HAM +++ 0.56 ± 0.05 81 ± 9.4 0.29 ± 0.08 *** 50 ± 7.5 *
T3 TG-7-ROM + 0a - 0a -
T4 TG-14-RAV +++ 1.11 ± 0.08 73 ± 6.7 0.71 ± 0.04 ** 54 ± 4.7 *
T6 TG-5-RAI +/- 0a - 0a -
T7 TG-14-CHA +++ 0.45 ± 0.08 48 ± 4.2 0.22 ± 0.01 *** 35 ± 4.4 *
T8 TG-20-THO +/- 0a - 0a -
  1. a, cut off : a tumor which exhibited less than 15 migrating cells distance of migration, if any, less than 50 μm, was considered non invasive.
  2. § Xenograft tumor nomenclature as originally described by Leuraud et al (2003).
  3. n = 7–10 per group and condition. ***, p < 0.001. **, p < 0.01, *, p < 0.05