TY - JOUR AU - Valdimarsdottir, Gudrun AU - Goumans, Marie-José AU - Itoh, Fumiko AU - Itoh, Susumu AU - Heldin, Carl-Henrik AU - Dijke, Peter ten PY - 2006 DA - 2006/03/29 TI - Smad7 and protein phosphatase 1α are critical determinants in the duration of TGF-β/ALK1 signaling in endothelial cells JO - BMC Cell Biology SP - 16 VL - 7 IS - 1 AB - In endothelial cells (EC), transforming growth factor-β (TGF-β) can bind to and transduce signals through ALK1 and ALK5. The TGF-β/ALK5 and TGF-β/ALK1 pathways have opposite effects on EC behaviour. Besides differential receptor binding, the duration of TGF-β signaling is an important specificity determinant for signaling responses. TGF-β/ALK1-induced Smad1/5 phosphorylation in ECs occurs transiently. SN - 1471-2121 UR - https://doi.org/10.1186/1471-2121-7-16 DO - 10.1186/1471-2121-7-16 ID - Valdimarsdottir2006 ER -