Figure 5

Cytoskeletal rearrangements by thalidomide. ECs were treated with different doses of thalidomide (25, 50 and 75 μg/ml). Representativeimage of ECs treated with 75 μg/ml thalidomide, depicts that thalidomide induces central micro filaments (arrows, thalidomide +) and reduces the number of lamellipodia in comparison to the control cell treated with DMSO, the vehicle only (arrows, thalidomide -). Further, we observed three sub populations of the central microfilaments in thalidomide treated cells, thick (thicker broken arrow), medium thick (thin broken arrow) and a thin centre microfilament (arrow head).