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Table 4 Effect of the inhibitors of tryptase or elastase on tryptase or elastase induced release of IL-8 from A549 cells

From: Induction of release and up-regulated gene expression of interleukin (IL)-8 in A549 cells by serine proteinases

Compound (μg/ml)

IL-8 released (pg/ml)

Medium alone

24.6 ± 1.5

Tryptase 2.0

105.2 ± 5.3*

Elastase 0.3

108.4 ± 13.2*

Benzamidine 30

37.6 ± 4.4

Leupeptine 30

27.4 ± 5.6

MSACK 30

22.1 ± 4.3

Tryptase 2.0 + Benzamidine 30

66.9 ± 4.8†

Tryptase 2.0 + Leupeptin 30

100 ± 1.7

Elastase 0.3 + MSACK 30

26.9 ± 3.6†

  1. Data shown are mean ± SE for five to six separate experiments. Stimulus, inhibitor, or stimulus with inhibitor was incubated with cells for 16 h. * P < 0.05 compared with the response to medium alone; †P < 0.05 compared with the corresponding stimulus alone.
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BMC Molecular and Cell Biology

ISSN: 2661-8850

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