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Table 4 Effect of the inhibitors of tryptase or elastase on tryptase or elastase induced release of IL-8 from A549 cells

From: Induction of release and up-regulated gene expression of interleukin (IL)-8 in A549 cells by serine proteinases

Compound (μg/ml) IL-8 released (pg/ml)
Medium alone 24.6 ± 1.5
Tryptase 2.0 105.2 ± 5.3*
Elastase 0.3 108.4 ± 13.2*
Benzamidine 30 37.6 ± 4.4
Leupeptine 30 27.4 ± 5.6
MSACK 30 22.1 ± 4.3
Tryptase 2.0 + Benzamidine 30 66.9 ± 4.8
Tryptase 2.0 + Leupeptin 30 100 ± 1.7
Elastase 0.3 + MSACK 30 26.9 ± 3.6
  1. Data shown are mean ± SE for five to six separate experiments. Stimulus, inhibitor, or stimulus with inhibitor was incubated with cells for 16 h. * P < 0.05 compared with the response to medium alone; P < 0.05 compared with the corresponding stimulus alone.