Figure 1

DNA microarray analysis of proliferating and differentiated C2C12 cells. Three undifferentiated (baseline) and 3 differentiated (experimental) microarray data sets were obtained from a total of 6 Affymetrix mouse genome 430 2.0 GeneChips™ as described in Materials and Methods. Those genes for which the microarray data had a p-value < 0.05 and where the change was ≥~1.5 fold, were deemed to "significantly" change. The NETs that met these two criteria were graphed. (A) up- or down-regulated NETs; (B) NE proteins; (C) muscle differentiation markers. Asterisks indicate previously validated NETs [22]. The dash lines indicate a 1.5 fold change. Abbreviations: Lamin A associated peptide 2 (LAP2) and Myocyte enhancing factor 2C (MEF 2C). Synonym: SUN1 (Unc84a). NET14a is one of the two alternatively spliced transcripts appearing in the new gene annotations, for the originally described NET14.