Table 2 Migration of pancreatic cancer cells enhanced by IL-1α and its suppresion by anti-integrin, anti-uPAR antibodies

Control

32.0 ± 6.24

(0)

27.7 ± 3.09

(0)

33.3 ± 3.09

(0)

IL-1α

59.2 ± 6.65 ^a

(184.9)

47.0 ± 7.13 ^a

(170.0)

63.2 ± 7.13 ^a

(189.5)

IL-1α + IgG

58.3 ± 8.69 ^a

(182.3)

45.8 ± 6.82 ^a

(165.7)

62.5 ± 6.82 ^a

(187.5)

anti-α₆ integrin

21.0 ± 1.35 ^a

(65.6)

19.9 ± 2.21 ^a

(71.8)

23.6 ± 2.48 ^a

(70.9)

IL-1α + anti-α₆ integrin

23.0 ± 2.45 ^a

(71.9)

22.3 ± 3.34 ^a

(80.1)

23.3 ± 3.34 ^a

(70.0)

anti-β₁ integrin

21.1 ± 1.35 ^a

(65.9)

23.3 ± 1.41 ^a

(84.1)

22.1 ± 2.14 ^a

(66.4)

IL-1α + anti-β₁ integrin

23.7 ± 2.05 ^a

(74.0)

22.5 ± 2.75 ^a

(81.3)

23.7 ± 2.75 ^a

(71.0)

anti-uPAR

25.2 ± 2.31 ^a

(78.8)

20.1 ± 2.07 ^a

(72.6)

24.1 ± 1.18 ^a

(72.4)

IL-1α + anti-uPAR

24.5 ± 4.28 ^a

(76.6)

21.2 ± 2.48 ^a

(76.5)

24.8 ± 2.48 ^a

(76.5)