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Table 2 Migration of pancreatic cancer cells enhanced by IL-1α and its suppresion by anti-integrin, anti-uPAR antibodies

From: Interleukin-1α enhances the aggressive behavior of pancreatic cancer cells by regulating the α6β1-integrin and urokinase plasminogen activator receptor expression

  Pancreatic cancer cells (number of migrated cells)
  BxPC-3 Capan-2 SW1990
Control 32.0 ± 6.24 (0) 27.7 ± 3.09 (0) 33.3 ± 3.09 (0)
IL-1α 59.2 ± 6.65 a (184.9) 47.0 ± 7.13 a (170.0) 63.2 ± 7.13 a (189.5)
IL-1α + IgG 58.3 ± 8.69 a (182.3) 45.8 ± 6.82 a (165.7) 62.5 ± 6.82 a (187.5)
anti-α6 integrin 21.0 ± 1.35 a (65.6) 19.9 ± 2.21 a (71.8) 23.6 ± 2.48 a (70.9)
IL-1α + anti-α6 integrin 23.0 ± 2.45 a (71.9) 22.3 ± 3.34 a (80.1) 23.3 ± 3.34 a (70.0)
anti-β1 integrin 21.1 ± 1.35 a (65.9) 23.3 ± 1.41 a (84.1) 22.1 ± 2.14 a (66.4)
IL-1α + anti-β1 integrin 23.7 ± 2.05 a (74.0) 22.5 ± 2.75 a (81.3) 23.7 ± 2.75 a (71.0)
anti-uPAR 25.2 ± 2.31 a (78.8) 20.1 ± 2.07 a (72.6) 24.1 ± 1.18 a (72.4)
IL-1α + anti-uPAR 24.5 ± 4.28 a (76.6) 21.2 ± 2.48 a (76.5) 24.8 ± 2.48 a (76.5)
  1. IL-1α, interleukin-1α; uPAR, urokinase plasminogen activator receptor. All data are expressed as mean ± s.d. (% increase). The p-values indicate statistical significance between data in controls and presence of IL-α with/without respective antibodies. a p < 0.05.