Figure 8

Responses of Bax deletion mutants to an inductive stimulus. A-E, Cos-7 cells were transfected with indicated constructs as described in methods and apoptotic nuclear damage assessed 3–4 hours after the addition of STS (gray bars). The bars in black indicate apoptotic damage in the absence of STS. F, MEF that are deficient for both Bax and Bak were assessed for susceptibility to Bax, Bax 30–105 and Bax 30–192. Bax 30–105 was tested in the presence (gray bars) or absence (black bars) of STS. *p < 0.001