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Figure 6 | BMC Cell Biology

Figure 6

From: GSK-3 inhibitors induce chromosome instability

Figure 6

GSK-3 inhibitors weaken the spindle midzone. DLD-1 cells were incubated for 24 hours with GSK-3 inhibitors then fixed and stained to detect the microtubules and the chromosomes. (A) Projections of deconvolved image stacks showing representative mitotic spindles. Scale bar: 5 μm. (B) Graphs plotting tubulin intensity along the spindle axis. (C) Bar graphs plotting pole-pole distance. Values represent the mean and s.e.m. derived from at least 18 cells. (D) Bar graphs quantifying the tubulin intensity at the spindle midzone. Values represent the mean and s.e.m. derived from at least 15 cells. The cells in parts A-B were treated with either 2.5 μM 1-Azakenpaullone or 30 μM SB-415286

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