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Table 1 GSK-3 inhibitors used in this study

From: GSK-3 inhibitors induce chromosome instability

Compound Class Mechanism In vitro IC50 Conc. used in cells Ref.
SB-415286 Arylindole-maleimides ATP Competitor 78 nM 30 μM [44]
AR-A014418 Thiazole ATP Competitor 104 nM 20 μM [58]
1-Aza kenpaullone Benzazepinone ATP Competitor 18 nM 2.5 μM [57]
CHIR99021 Aminopyrimidine ATP Competitor 7 nM 10 μM [47]
Lithium Divalent ion Non competitive 2 mM 40 mM [41]
TDZD-8 Thiadiazolidinone Non competitive 2 μM 10–60 μM [70]
Inhibitor II Pyridyloxadiazole - 390 nM 25–75 μM [71]
OTDZT Thiadiazolidinone Non competitive 10 μM 50–100 μM [70]
Inhibitor XI Azaindolylmaleimide ATP Competitor 32 nM 50 μM [72]