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Table 2 Effect of SB-415286 inhibitors on mitotic timing

From: GSK-3 inhibitors induce chromosome instability

Compound

Event

Time (mins)

s.e.m.

Range

N

P

Untreated

NEB-Metaphase

21.59

1.49

12–72

41

-

 

Metaphase-Anaphase

10.65

0.92

1.5–35.5

49

-

SB-415286

NEB-Metaphase

46.04

4.32

17.5–162

42

p < 0.01

 

Metaphase-Anaphase

11.32

1.2

1.5–55

57

p > 0.05

  1. Values represent the mean time, in minutes, taken from nuclear envelope breakdown to metaphase and metaphase to anaphase in minutes. Also shown is showing the standard error of the mean, the range and the number of cells analysed. P values determined using a Kruskal-Wallis test.