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Table 3 Effect of GSK-3 inhibitors on mitotic timing and chromosome non-disjunction

From: GSK-3 inhibitors induce chromosome instability

Compound Time (mins) s.e.m. Range N # P
- 25.37 0.35 16–42 189 0 -
SB4 69.56 3.44 26–214 99 15 p < 0.001
AR 92.88 10.02 24–268 41 3 p < 0.001
Ken 31.87 0.48 20–82 348 2 p < 0.001
CHIR 43.94 1.93 20–214 187 8 p < 0.001
  1. Values represent the mean time, in minutes, taken from nuclear envelope breakdown to metaphase, Also shown is the standard error of the mean, the range, the number of cells analysed (N), the number of cells which enter anaphase with unaligned chromosomes (#). P values determined using a Kruskal-Wallis test.