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Table 3 Effect of GSK-3 inhibitors on mitotic timing and chromosome non-disjunction

From: GSK-3 inhibitors induce chromosome instability

Compound

Time (mins)

s.e.m.

Range

N

#

P

-

25.37

0.35

16–42

189

0

-

SB4

69.56

3.44

26–214

99

15

p < 0.001

AR

92.88

10.02

24–268

41

3

p < 0.001

Ken

31.87

0.48

20–82

348

2

p < 0.001

CHIR

43.94

1.93

20–214

187

8

p < 0.001

  1. Values represent the mean time, in minutes, taken from nuclear envelope breakdown to metaphase, Also shown is the standard error of the mean, the range, the number of cells analysed (N), the number of cells which enter anaphase with unaligned chromosomes (#). P values determined using a Kruskal-Wallis test.