Drosophila DNA Ligase I is targeted to RF in mouse but not in Drosophila cells. (A) Organization of domains in DmDNA Lig I is shown at the top and below the various deletions of DmDNA Lig I fused to GFP. The predicted molecular weight of the fusion proteins is indicated on the left. The targeting to RF of each fusion in mammalian and Drosophila cells is summarized on the right. (B and C) Subcellular localization of the DmDNA Lig I (GdL, B) and DmLigPBD-GFP (C) with respect to BrdU labeled RF in S2 cells (upper panel) and C2C12 cells (bottom panel). Scale Bar = 2 μm.