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Table 1 Prediction of mitochondrial targeting of HCCR-1 and LETM1 domain-containing proteins.

From: HCCR-1, a novel oncogene, encodes a mitochondrial outer membrane protein and suppresses the UVC-induced apoptosis

  

TargetP

Predotar

  

Score

RC

Score

Human

AAH21208

0.882

2

0.74

 

AAK34885

0.898

1

0.39

Mouse

AAH55685

0.442

4

0.04

Fly

AAM68317

0.932

2

0.04

 

CAA71125

0.861

2

0.72

Squirt

AAC37181

0.670

4

0.68

Worm

NP_506382

0.943

2

0.84

Fungi

NP_014615

0.924

1

0.75

 

AAB70096

0.822

3

0.78

 

AAS50397

0.934

1

0.85

 

AAS50381

0.920

1

0.81

 

XP_330653

0.798

2

0.10

Plant

NP_176732

0.634

4

0.09

  1. Mitochondrial targeting sequences were detected by TargetP version 1.1 [16] and Predotar version 1.03 [17]. TargetP calculates relative for mitochondrial localization. The reliability classes (RC) of TargetP provide a score from 1 to 5, where 1 indicates the strongest prediction. Predotar provides a probability estimate as to whether the sequence contains a mitochondrial targeting sequence. Proteins with scores above 0.5 are very probably targeted to the mitochondria.