Figure 9

Effects of recombinant adiponectin and AICAR treatments on BrdU incorporation by MC3T3-E1 cells. Cells were exposed to 0.01–1.0 μg/ml adiponectin or 0.01–0.5 mM AICAR for 24 h. Cell proliferation was determined by measuring the amount of incorporated BrdU. Proliferation was significantly promoted by both low dose adiponectin (A) and AICAR (B) treatments (p < 0.01). The results were the representative of three different experiments.