Disruption of Four Kinesin Genes in Dictyostelium

Table 2 Mitotic kinesin disruptions in simple eukaryotes vs metazoans.

Kinesin Family	*S. cerevisiae*	*Dictyostelium*	*C. elegans*	*Drosophila*	Human
Mitotic Function
Kinesin-4 (Chromokin)		Kif8	Klp-19	Klp3A	Kif4A, Kif4B
Kinesin-5 (BimC/Eg5)	Cin8, Kip1	Kif13	BMK1	Klp61F	Eg5
Kinesin-6 (MKLP)		Kif12	Zen-4	Pavarotti	MKLP1, MKLP2
Kinesin-7 (CENP-E)	Kip2	Kif4, Kif11		CENP-E Meta	CENP-E
Kinesin- 8 (Kip3)	Kip3	Kif10		Klp67A	Kif18
Kinesin-13 (MCAK)		?	Klp-7	KLP10A	Kif2A, 2B, MCAK
Kinesin-14 (NCD/Kar3)	Kar3	Kif2	Klp-3,15,16,17	Ncd	KifC1
Other Function
Kinesin-3 (Unc104)		Kif1			Kif14
Kinesin-10 (Nod)				Nod	Kid
Kinesin12 (Xklp2)			Klp-18

Normal text (viable), italicized text (not viable) differentiates the individual kinesin-isoform disruptions (knockout, knockdown, or mutation) and their effects on mitosis. The bold text for the kinesin-6 family members indicates cytokinesis defects. In this case, cells can proceed through one or more divisions, but longer term, the mutated protein is essential for organism viability. References for S.c [5], D.d[7-10, 12-14], C.e [39, 47-51], D.m [40], and H.s [15, 52].

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