|
Kinesin Family
|
S. cerevisiae
|
Dictyostelium
|
C. elegans
|
Drosophila
|
Human
|
|---|
|
Mitotic Function
| | | | | |
|
Kinesin-4 (Chromokin)
| |
Kif8
|
Klp-19
|
Klp3A
|
Kif4A, Kif4B
|
|
Kinesin-5 (BimC/Eg5)
|
Cin8, Kip1
|
Kif13
|
BMK1
|
Klp61F
|
Eg5
|
|
Kinesin-6 (MKLP)
| |
Kif12
|
Zen-4
|
Pavarotti
|
MKLP1, MKLP2
|
|
Kinesin-7 (CENP-E)
|
Kip2
|
Kif4, Kif11
| |
CENP-E Meta
|
CENP-E
|
|
Kinesin- 8 (Kip3)
|
Kip3
|
Kif10
| |
Klp67A
|
Kif18
|
|
Kinesin-13 (MCAK)
| |
?
|
Klp-7
|
KLP10A
|
Kif2A, 2B, MCAK
|
|
Kinesin-14 (NCD/Kar3)
|
Kar3
|
Kif2
|
Klp-3,15,16,17
|
Ncd
|
KifC1
|
|
Other Function
| | | | | |
|
Kinesin-3 (Unc104)
| |
Kif1
| | |
Kif14
|
|
Kinesin-10 (Nod)
| | | |
Nod
|
Kid
|
|
Kinesin12 (Xklp2)
| | |
Klp-18
| | |
- Normal text (viable), italicized text (not viable) differentiates the individual kinesin-isoform disruptions (knockout, knockdown, or mutation) and their effects on mitosis. The bold text for the kinesin-6 family members indicates cytokinesis defects. In this case, cells can proceed through one or more divisions, but longer term, the mutated protein is essential for organism viability. References for S.c [5], D.d[7-10, 12-14], C.e [39, 47-51], D.m [40], and H.s [15, 52].
