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Table 1 Expression patterns of FUS, EWS and TAF15 in human tissues by TMA immunohistochemistry analysis

From: The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response

   FUS EWS TAF15
Organ Tissue/Cell type Nuclear Cytoplasmic Nuclear Cytoplasmic Nuclear Cytoplasmic
Adrenal gland Parenchymal cells +++ +++ +++ - +++ +++
Appendix Appendix smooth muscle +++ +++ +++ - +++ +++
Brain        
- white matter Glial cells +++ - +++ - +++ -
- grey matter Neurons +++ + +++ - +++ +
Breast Glandular epithelium +++ +++ +++ - +++ +++
  Myoepithelial cells +++ +++ ++ - +++ +++
  Endothelium, capillaries +++ ++ +++ - +++ +++
  Adipocytes +++ - +++ - +++ -
Colon & Rectum Surface epithelium +++ +++ ++ - +++ +++
  Crypt epithelium +++ +++ ++ - +++ +++
  Malt tissue, germinal centre +++ - +++ - +++ -
  Malt tissue, mantle zone +++ - +++ - ++ -
Duodenum Enterocytes, villus epithelium +++ +++ ++ - +++ +++
  Enterocytes, crypt epithelium +++ +++ ++ - +++ +++
  Ganglion cells +++ +++ +++ - +++ +++
Endometrium        
- proliferative Glandular epithelium +++ +++ +++ - +++ +++
  Stromal cells +++ - ++ - +++ -
- secretory Glandular epithelium +++ +++ +++ - +++ +++
  Stromal cells ++ - ++ - ++ -
Esophagus Squamous epithelium, suprabasal +++ +++ +++ - +++ +++
  Squamous epithelium, basal ++ +++ + - ++ +++
  Endothelium, medium-sized arteries +++ + +++ - +++ ++
  Smooth muscle cells +++ +++ +++ - +++ +++
Gallbladder Mucosal epithelium +++ +++ +++ +++ +++ +++
  Smooth muscle cells +++ +++ +++ - +++ +++
Heart Cardiac muscle cells - - - - - -
  Cardiac endothelium - - ++ - - -
Kidney Glomeruli ++ - ++ - ++ -
  Proximal tubuli +++ +++ +++ +++ +++ +++
  Distal tubuli +++ +++ +++ +++ +++ +++
Liver Hepatocytes - +++ ++ +++ - +++
  Bile duct epithelium +++ +++ +++ +++ +++ +++
Lung & Bronchus Respiratory epithelium +++ +++ +++ - +++ +++
  Glandular epithelium +++ +++ +++ - +++ +++
  Pneumocytes ++ - ++ - ++ +
  Chondrocytes +++ - ++ - ++ -
  Endothelium, capillaries +++ - +++ - +++ -
  Muscle artery, endothelial cells +++ - +++ - +++ -
  Muscle artery, smooth muscle +++ +++ +++ - +++ +++
Lymph node Germinal centre ++ - ++ - ++ -
  Mantle zone ++ - ++ - ++ -
Myometrium Smooth muscle cells + - + - + -
Nasal mucosa Respiratory epithelium +++ ++ ++ - +++ ++
  Glandular epithelium +++ +++ +++ - +++ +++
Ovary Follicular epithelium +++ +++ ++ - +++ +++
  Ovarial stromal cells +++ - +++ - +++ -
Pancreas Exocrine glands +++ +++ +++ - +++ +++
  Duct epithelium +++ +++ +++ - +++ +++
  Endocrine cells +++ +++ +++ +++ +++ +++
Placenta Syncytiotrophoblasts ++ ++ + + ++ +++
  Cytotrophoblasts +++ + ++ + +++ +
Prostate Prostate epithelium + + ++ + ++ +
  Basal cells +++ - +++ - ++ -
Salivary gland Serous cells +++ +++ +++ ++ +++ +++
  Mucous cells +++ + ++ - +++ +
  Intercalated/striated ducts +++ +++ +++ +++ +++ +++
  Myoepithelium +++ - +++ - +++ -
Salpinx Glandular epithelium +++ +++ +++ - +++ +++
Seminal vesicle Epithelium +++ +++ +++ +++ +++ +++
Skeletal muscle Skeletal muscle fibers ++ - ++ - +++ -
Skin & Subcutis Keratinocytes +++ +++ +++ - +++ +++
  Melanocytes - - - - - -
  Fibroblasts +++ - +++ - +++ -
  Ecrine epithelium, sweat gland +++ +++ ++ - +++ +++
  Endothelium, capillaries +++ - +++ - +++ -
  Adipocytes +++ - ++ - ++ -
Spleen Lymphocytes, red and white pulp ++ - ++ - + -
Stomach        
- body Surface & foveolar epithelium +++ +++ +++ - +++ +++
  Specialized glandular epithelium + +++ + +++ + +++
- antrum Surface & foveolar epithelium +++ +++ ++ - +++ +++
  Specialized glandular epithelium +++ +++ ++ - +++ ++
- smooth muscle Smooth muscle cells +++ - +++ - +++ -
Small bowel Enterocytes, villus epithelium +++ +++ ++ - +++ +++
  Enterocytes, crypt epithelium +++ +++ ++ - +++ +++
  Ganglion cells +++ +++ +++ +++ +++ +++
Testis Germinal epithelium +++ - +++ - +++ -
  Leydig intestitial cells ++ ++ ++ - ++ +++
  Spermatides + - + - ++ -
Thymus T-lymphocytes ++ - ++ - ++ -
  Epithelium +++ + +++ - +++ +++
Thyroid Follicular epithelium +++ +++ ++ - +++ +++
Tonsil Squamous cell epithelium +++ +++ +++ - +++ +++
  Lymphocytes +++ - +++ - +++ -
Umbilical cord Stromal cells +++ ++ ++ - +++ ++
Urinary bladder Urothelium +++ +++ +++ - +++ +++
Uterine cervix Squamous epithelium, basal +++ +++ ++ - +++ +++
  Squamous epithelium, suprabasal +++ +++ +++ - +++ +++
  1. The percentage of FET positive cells within an organ is indicated as: +++ (100-76% positively staining cells), ++ (75-26% positively staining cells), + (25-1% positively staining cells) and - (negative).