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Figure 7 | BMC Cell Biology

Figure 7

From: The androgen receptor can signal through Wnt/β-Catenin in prostate cancer cells as an adaptation mechanism to castration levels of androgens

Figure 7

Working model for the interaction of AR and Wnt/β-Catenin signaling pathway in castration-resistant prostate cancer cells. In normal conditions, Wnt and androgen signaling function at different cell populations (A&B). In prostate cancer where both pathways may be deregulated in the same cells, androgens may inhibit the input of AR into the Wnt signaling pathway where β-Catenin can potentiate the AR signaling (C). In castration-resistant prostate cancer cells, Wnt can activate both signaling pathways turning the unliganded AR into a coactivator of the Wnt dependent transcriptional program (D).

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