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Table 1 Angiogenesis-related genes modulated by CRP in HCAEC

From: C-reactive protein exerts angiogenic effects on vascular endothelial cells and modulates associated signalling pathways and gene expression

Gene name

Fold-increase (time)

Experiment #1

Fold-increase (time)

Experiment #2

Gene function

KDR/Flk-1/VEGFR2

1.53 (12 h)

1.94 (24 h)

Cell survival, proliferation and angiogenesis44

PDGF-B

2.44 (24 h)

3.94 (12 h)

Proliferation and angiogenesis45

Notch1

3.28 (12 h)

1.97 (12 h)

Angiogenesis (spreading and branching)46

Notch3

2.03 (24 h)

4.46 (72 h)

Vascular cell identity and survival47,48

CYR61/CCN1

4.94 (72 h)

3.91 (12 h)

Connective tissue growth factor 49

ID1

2.65 (24 h)

1.94 (12 h)

Cell cycle and angiogenesis50

  1. PDGF, Platelet-derived growth factor; KDR: kinase-insert domain receptor; VEGFR2, vascular endothelial cell growth factor receptor-2; CYR61, Cysteine-rich angiogenic inducer 6; ID1, Inhibitor of DNA binding/differentiation-1.
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BMC Molecular and Cell Biology

ISSN: 2661-8850

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