Table 1 Gene expression changes after 2 and 4 hours of PI 3-kinase inhibition
Up-Regulated Genes | Down-Regulated Genes | ||
|---|---|---|---|
Gene Symbol | Gene Name | Gene Symbol | Gene Name |
APOLD1 | Apolipoprotein L domain containing 1 | AMD1 | S-adenosylmethionine decarboxylase 1 |
Atrogin-1 | F-box protein 32/Atrogin-1 | AMIGO2 | Adhesion molecule with Ig-like domain 2 |
BCL6 | B-cell CLL/lymphoma 6 | ATP13A3 | ATPase type 13A3 |
BTG1 | B-cell translocation gene 1 | BAG2 | BCL2-associated athanogene 2 |
C1orf183 | Chromosome 1 open reading frame 183 | BDNF | Brain-derived neurotrophic factor |
C1orf63 | Chromosome 1 open reading frame 63 | BIRC3/cIAP2 | Baculoviral IAP repeat-containing 3 |
CCNG2 | Cyclin G2 | CCL2 | Chemokine (C-C motif) ligand 2 |
CLK1 | CDC-like kinase 1 | CCND1 | Cyclin D1 |
CTGF | Connective tissue growth factor | CYP1B1 | Cytochrome P450 subfamily I polypeptide 1 |
DDIT3/CHOP | DNA-damage-inducible transcript 3 | DCK | Deoxycytidine kinase |
EIF1/SUI1 | Eukaryotic translation initiation factor 1 | DIO2 | Deiodinase, iodothyronine, type II |
GADD45B | Growth arrest and DNA-damage-inducible β | DKFZP686E2158 | Hypothetical protein LOC643155 |
ID1 | Inhibitor of DNA binding 1 | DKK1 | Dickkopf homolog 1 (Xenopus laevis) |
ID2B | Striated muscle contraction regulatory prot. | DSCR1 | Down syndrome critical region gene 1 |
IRF7 | Interferon regulatory factor 7 | EDN1 | Endothelin 1 |
KIF1B | Kinesin family member 1B | F3 | Coagulation factor III |
KLF6 | Kruppel-like factor 6 | FGF2 | Fibroblast growth factor 2 |
KLHL24 | Kelch-like 24 | FST | Follistatin |
LOC85028 | PNAS-123 | G0S2 | Putative lymphocyte G0/G1 switch gene |
MIR | Myosin regulatory light chain interacting prot. | GABPB2 | GA binding protein transcription factor, β2 |
MT1E | Metallothionein 1E | GBP1 | Guanylate binding protein 1 |
PCMTD1 | Protein-L-isoaspartate O-methyltransferase | GBP3 | Guanylate binding protein 3 |
PHLDA1 | Pleckstrin homology-like domain family A | GLIPR1 | Glioma pathogenesis-related protein |
PNPLA8 | Patatin-like phospholipase domain 8 | GPR19 | G protein-coupled receptor 19 |
RNU2 | RNA, U2 small nuclear | GRIK1 | Glutamate receptor, ionotropic, kainate 1 |
SAT | Spermine N1-acetyltransferase | GRO3 | GRO3 oncogene |
STK31 | Serine/threonine kinase 31 | IGFBP5 | Insulin-like growth factor binding protein 5 |
TAF9 | TAF9 RNA polymerase II | IL7R | Interleukin 7 receptor |
TIEG | TGFβ inducible early growth response | ISG20L1 | Interferon stimulated exonuclease |
TXNIP | Thioredoxin interacting protein | LOC57090 | HRPAP20 short form |
ZBTB1 | Zinc finger and BTB domain containing 1 | LTV1 | LTV1 homolog (S. cerevisiae) |
cDNA DKFZp564C2063 | MAT2A | Methionine adenosyltransferase II, alpha | |
MMP3 | Matrix metalloproteinase 3 | ||
NAV3 | Neuron navigator 3 | ||
NCOA7 | Nuclear receptor coactivator 7 | ||
NOLA1 | Nucleolar protein family A, member 1 | ||
NTF3 | Neurotrophin 3 | ||
NXT1 | NUTF-like export factor1 | ||
PAK1IP1 | PAK1 interacting protein 1 | ||
PLAU | Plasminogen activator, urokinase | ||
PPIF | Peptidylprolyl isomerase F (cyclophilin F) | ||
PTRH2 | Peptidyl-tRNA hydrolase 2 | ||
PTX3 | Pentaxin-related gene | ||
RGS20 | Regulator of G-protein signalling 20 | ||
SC4MOL | Sterol-C4-methyl oxidase-like | ||
SFRS3 | Splicing factor, arginine/serine-rich 3 | ||
SGNE1 | Secretory granule, neuroendocrine protein 1 | ||
SNK | Serum-inducible kinase | ||
STC2 | Stanniocalcin 2 | ||
TNFRSF11B | Tumor necrosis factor receptor 11b (OPG) | ||
TRIM16 | Tripartite motif-containing 16 | ||
TSLP | Thymic stromal lymphopoietin | ||
cDNA FLJ11812 fis, clone HEMBA1006364 | |||