Phosphatidylinositol 3-kinase signaling in proliferating cells maintains an anti-apoptotic transcriptional program mediated by inhibition of FOXO and non-canonical activation of NFκB transcription factors

Table 3 Summary of Gene Ontology (GO) term analysis.

GO ID	GO name	# Genes	% Genes	p-value
Up-regulated Genes
GO:0032502	Developmental process	15	60	0.00002
GO:0048869	Cellular developmental process	12	48	0.00003
GO:0030154	Cell differentiation	12	48	0.00003
GO:0000122	Negative regulation of transcription from RNA polymerase II promoter	4	16	0.00007
GO:0045892	Negative regulation of transcription, DNA-dependent	4	16	0.00033
GO:0006366	Transcription from RNA polymerase II promoter	6	24	0.00064
GO:0006950	Response to stress	7	28	0.00068
GO:0050794	Regulation of cellular process	14	56	0.00087
Down-regulated Genes
GO:0048519	Negative regulation of biological process	13	27	0.000040
GO:0007267	Cell-cell signaling	10	21	0.000040
GO:0007154	Cell communication	23	48	0.000077
GO:0012501	Programmed cell death	10	21	0.000083
GO:0048523	Negative regulation of cellular process	12	25	0.000085
GO:0007165	Signal transduction	21	44	0.000130
GO:0008219	Cell death	10	21	0.000134
GO:0016265	Death	10	21	0.000134
GO:0009887	Organ morphogenesis	7	15	0.000169
GO:0009605	Response to external stimulus	8	17	0.000432
GO:0042221	Response to chemical stimulus	7	15	0.000490
GO:0007166	Cell surface receptor linked signal transduction	12	25	0.000632
GO:0009653	Anatomical structure morphogenesis	10	21	0.000840

All GO terms in the Biological Process category that were significantly enriched [p ≤ 0.001, Fisher's exact test [76]] amongst the genes changing expression after 2 and 4 hours of LY294002 treatment and were represented in at least 15% of the genes containing GO definitions are listed. The GO ID and name are shown along with the number and percentage of genes that are assigned this term.

ISSN: 2661-8850