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Figure 6 | BMC Cell Biology

Figure 6

From: The osteogenic or adipogenic lineage commitment of human mesenchymal stem cells is determined by protein kinase C delta

Figure 6

PKCδ regulates bone formation in a direct and indirect manner. The direct pathway is dependent on osteogenesis. The endogenous PKCδ in hBMSCs strongly stimulates the RUNX2 activity, thereby facilitating RUNX2-mediated osteogenic differentiation. The indirect pathway is independent on osteogenesis, which includes the potential negative regulation of adipogenic differentiation.

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