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Figure 4 | BMC Cell Biology

Figure 4

From: Protease 3C of hepatitis A virus induces vacuolization of lysosomal/endosomal organelles and caspase-independent cell death

Figure 4

Ultrastructural analysis of 3Cpro-induced vacuoles. Cytoplasmic vacuoles in A549/3Cpro and Calu-1/3Cpro cells were analyzed by electron microscopy. A. Vacuoles bounded by a single membrane layer. B. Vacuoles with blurred boundaries. C. Vesicles neighboring vacuoles. Vesicles inside vacuoles are indicated by triangles; multimembrane formations, m; small vesicles neighboring vacuoles, *. Scale, 0.5 μm.

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