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Table 4 Gene expression analysis: Normalized fold increase of H-HA/L-HA complex 0.1 and 1 % (w/v), relative to gene expression transforming growth factor beta 1 (TGF-β1) and Type I collagen (COLIA1) at different time of analysis. Data represent the mean ± SD of three independent experiments

From: In vitro analysis of the effects on wound healing of high- and low-molecular weight chains of hyaluronan and their hybrid H-HA/L-HA complexes

  TGF-β1 COLIA1
H-HA/L-HA complex (% w/v) 0.1 1 0.1 1
4h ↓↓ ↓ ~ =
10 h ↑ ↓ ↑ ↓
16 h ↑ ↓ ↑ ↑↑
24 h = = = ↓
  1. Legend: = as the control, ↑ 1.2–5 fold vs control, ↑↑ 5.2–10 fold vs control, ↑↑↑ >10 fold vs control, ↓ 0.1–0.7, ~ 0.8–0.9 fold vs control, ↓↓ < 0.1 fold vs control
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