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Table 4 Gene expression analysis: Normalized fold increase of H-HA/L-HA complex 0.1 and 1 % (w/v), relative to gene expression transforming growth factor beta 1 (TGF-β1) and Type I collagen (COLIA1) at different time of analysis. Data represent the mean ± SD of three independent experiments

From: In vitro analysis of the effects on wound healing of high- and low-molecular weight chains of hyaluronan and their hybrid H-HA/L-HA complexes

 

TGF-β1

COLIA1

H-HA/L-HA complex (% w/v)

0.1

1

0.1

1

4h

↓↓

↓

~

=

10 h

↑

↓

↑

↓

16 h

↑

↓

↑

↑↑

24 h

=

=

=

↓

  1. Legend: = as the control, ↑ 1.2–5 fold vs control, ↑↑ 5.2–10 fold vs control, ↑↑↑ >10 fold vs control, ↓ 0.1–0.7, ~ 0.8–0.9 fold vs control, ↓↓ < 0.1 fold vs control