Fig. 7
From: EGF-induced sodium influx regulates EGFR trafficking through HDAC6 and tubulin acetylation
Schematic model. a Resting cell in the absence of ligand. b Ligand-binding leading to increased intracellular sodium and increased tubulin acetylation (mediated through inhibition of HDAC6). c The ligand-receptor complex is internalized and trafficked for degradation. d The ligand-receptor complex is degraded and signaling is terminated. Na,K-ATPase restores low intracellular sodium levels.