Analysis of the ways and methods of signaling pathways in regulating cell cycle of NIH3T3 at transcriptional level

Table 2 Signaling pathways that cell cycle-associated genes involved at different time points

Time	5h	10h	15h	18h	21h	21.5h	22h	23.5h	25h
Cell cycle	G0/G1 check point	G1 phase	G1/S check point	S phase	S check point	G2 phase	G2/M check point	M check point	End of M phase
14-3-3-mediated Signaling	~	-	+/-	~	-	~	~	~	~
Antiproliferative Role of Somatostatin Receptor 2	-	+	-	+	~	~	~	~	+
Aryl Hydrocarbon Receptor Signaling	+/-	+/-	+/-	+/-	+/-	+/-	+/-	+/-	+/-
ATM Signaling	+/-	-	+/-	+/-	+/-	+/-	+/-	-	-
CDK5 Signaling	+/-	-	-	+/-	+/-	+/-	+/-	+/-	+/-
Cell Cycle Control of Chromosomal Replication	~	+	+	+	+	+	+	+	+
Ceramide Signaling	-	+	+	+	+	+	+	~	+
Cyclins and Cell Cycle Regulation	+/-	+	+	+	+	+	-	-	-
DNA damage-induced 14-3-3σ Signaling	-	+/-	+/-	+/-	+/-	+/-	+	+	+
Estrogen-mediated S-phase Entry	+	+	+	+	+	+	+	+	+
G1/S Check Point Regulation	~	+	+	+	+	+	+	+	+
G2/M DNA Damage Check Point Regulation	+	+	~	+	+	+	+	+	+
GADD45 Signaling	+/-	+	+/-	+/-	+/-	+/-	+	+	+
Integrin Signaling	+/-	+/-	+/-	+/-	+/-	~	~	~	~
Mitotic Role of Polo-Like Kinase	+	+	+	+	+	+	+	+	+
Role of CHK Proteins in Cell Cycle Checkpoint	-	-	-	-	-	-	-	-	-
Tight Junction Signaling	-	-	-	+	~	~	~	~	-

^a “+” represents the signaling pathway promote the down-stream physiological activity associated with cell cycle progression, “-” represents the signaling pathway inhibit the physiological activity, “~” represents the signaling pathway has little impact on the physiological activity

ISSN: 2661-8850