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Table 2 Signaling pathways that cell cycle-associated genes involved at different time points

From: Analysis of the ways and methods of signaling pathways in regulating cell cycle of NIH3T3 at transcriptional level

Time 5h 10h 15h 18h 21h 21.5h 22h 23.5h 25h
Cell cycle G0/G1 check point G1 phase G1/S check point S phase S check point G2 phase G2/M check point M check point End of M phase
14-3-3-mediated Signaling ~ - +/- ~ - ~ ~ ~ ~
Antiproliferative Role of Somatostatin Receptor 2 - + - + ~ ~ ~ ~ +
Aryl Hydrocarbon Receptor Signaling +/- +/- +/- +/- +/- +/- +/- +/- +/-
ATM Signaling +/- - +/- +/- +/- +/- +/- - -
CDK5 Signaling +/- - - +/- +/- +/- +/- +/- +/-
Cell Cycle Control of Chromosomal Replication ~ + + + + + + + +
Ceramide Signaling - + + + + + + ~ +
Cyclins and Cell Cycle Regulation +/- + + + + + - - -
DNA damage-induced 14-3-3σ Signaling - +/- +/- +/- +/- +/- + + +
Estrogen-mediated S-phase Entry + + + + + + + + +
G1/S Check Point Regulation ~ + + + + + + + +
G2/M DNA Damage Check Point Regulation + + ~ + + + + + +
GADD45 Signaling +/- + +/- +/- +/- +/- + + +
Integrin Signaling +/- +/- +/- +/- +/- ~ ~ ~ ~
Mitotic Role of Polo-Like Kinase + + + + + + + + +
Role of CHK Proteins in Cell Cycle Checkpoint - - - - - - - - -
Tight Junction Signaling - - - + ~ ~ ~ ~ -
  1. a “+” represents the signaling pathway promote the down-stream physiological activity associated with cell cycle progression, “-” represents the signaling pathway inhibit the physiological activity, “~” represents the signaling pathway has little impact on the physiological activity