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Fig. 6 | BMC Cell Biology

Fig. 6

From: Dissecting seipin function: the localized accumulation of phosphatidic acid at ER/LD junctions in the absence of seipin is suppressed by Sei1pΔNterm only in combination with Ldb16p

Fig. 6

Working model for PA puncta in seipin-deleted cells. ER-droplet interface is shown. Left, normally, PA fluxes from generating to metabolizing enzymes. PA flux through the TAG pathway into droplets is not specifically shown. Curvature at the junction is mild or it protected by seipin. Right, in the absence of seipin, some PA is trapped at the ER-drop interface in regions of high curvature, creating punta seen by fluorescence probes

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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