Fig. 5
From: Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells
Model for the direct and indirect interaction of Rap1 with talin in Dictyostelium and mammalian cells. Rap-mediated activation of TalinA induces basal adhesion, possibly through binding to the RA domain of Phg2 in Dictyostelium or RIAM in mammalian cells. Activated Rap can also bind directly to the RA domain of TalinB, thereby inducing additional adhesion for force-demanding processes