Fig. 10
From: Spatiotemporal patterns of sortilin and SorCS2 localization during organ development
SorCS2 expression in embryonic internal organs. Immunohistofluorescence was performed on sagittal sections (10 μm) of embryos on embryonic day E13.5, E15.5 and E17.5. SorCS2 is found prominently in the epithelium of the developing lung, and also the visceral pleural layer (a-c) It is highly expressed in the liver at E13.5 (d), but diminishes at later time points and instead localizes to central veins (e,f). SorCS2 is also expressed in the cap mesenchyme of the kidney (g-i), and in the connective tissue of the gut (j-l). Green channel is SorCS2, red channel is TTF-1 and blue channel is Hoechst nuclear stain. Scale bars = 50 μm. Br, bronchus; Cp, Cap mesenchyme; Cv, central vein; Ki, kidney; Li, liver; Lu, lumen; Pl pleuric cavity; Si, small Intestine; SMe, submesothelial connective tissue; SMu, submucosal connective tissue