Fig. 8
From: Molecular mechanisms regulating formation, trafficking and processing of annular gap junctions
Schematic representation of the signals and players that participate in the steps that lead to gap junction internalization, formation of annular gap junctions in the cytoplasm of the acceptor cell, and annular gap junction degradation through the phago-lysosomal (bottom right) or the endo-lysosomal (bottom left) pathway based on published studies. Abbreviations are: AGJ, annular gap junction; CLASPs, clathrin-associated sorting proteins; ESCRT, endosomal sorting complexes required for transport; GJ, gap junction; p62, sequestosome 1/SQSTM1; UBA, ubiquitin-associated domain; UIMs, ubiquitin-interacting motifs. (From ref. [182])