Fig. 2

Proteasomal degradation of Cx43 via ERAD: CIP75 binds to the C-terminal tail of ER-localized Cx43 via its UBA domain, and then facilitates the translocation of Cx43 from the ER membrane into the cytosol. This complex interacts with 19S proteasome subunit via the CIP75 UBL domain, leads to the proteasomal degradation