|
Cx43
|
Breast
|
Different effects on MCF-7 and MDA-MB231 in 2-D and 3-D cell cultures
|
[65]
|
|
Cx43
|
Breast
|
Peptide ACT1 increase GJ and impairs cell proliferation/survival
|
[116]
|
|
Cx43
|
Breast
|
CM from breast cancer cells decreases Cx43 gap junctions
|
[96]
|
|
Cx43
|
Gastric cancer cells
|
Increase in diapedesis and transmigration through intercellular space between mesothelial cells
|
[90]
|
|
Cx43
|
Mammalian cancer stem-like cells
|
miRNA-206 represses pro-apoptotic PDCD4 and Cx43
|
[76]
|
|
Cx43
|
Prostate
|
With Snail-1 to repress E-cadherin and promotes EMT, mobility and invasiveness
|
[88]
|
|
Cx43
|
Prostate
|
Cx43 knockdown, not gap junctions inhibits migration/invasion of four prostate cancer cell lines
|
[98]
|
|
Cx43
|
Osteosarcoma
|
miRNA-23a suppresses Cx43
|
[77]
|
|
Cx43
|
Neuroblastoma & glioma, leukemia
|
A direct link of Cx43 and CCN in anti-proliferative function
|
[67]
|
|
Cx43
|
C6 glioma
|
Cx43 antibody in rats increases survival and even more with radiotherapy
|
[122]
|
|
Cx43
|
Glioma
|
Cx43 increases resistance to TMZ via mitochondrial apoptosis pathway
|
[136]
|
|
Cx43
|
Astrocytomas & glioblastomas
|
Increased Cx43 expression in human tumors
|
[125]
|
|
Cx43
|
Brain metastasis
|
GJ with endothelial cells to promote metastatic lesion
|
[86]
|
|
Cx43
|
Lung adenocarcinoma
|
Increased incidence by DMBA in Cx43 heterozygous knockout mice
|
[62]
|
|
Cx43
|
Non-small Lung cancer
|
Cx43 reduction as a marker for cisplatin-chemotherapy
|
[132]
|
|
Cx43
|
Non-small Lung cancer
|
Cx43 overexpression reverses EMT and cisplatin resistance and deletion has opposing effects
|
[134]
|
|
Cx43
|
Glioblastoma multiforme (GBM)
|
HCMV reduces Cx43 and gap junctions
|
[64]
|
|
Cx43
|
GBM
|
Cx43 increased in TMZ-resistant cells by EGFR signaling
|
[135]
|
|
Cx43
|
Mesothelioma
|
Increases sensitivity to sunitinib via interaction with Bax
|
[109]
|
|
Cx43
|
Oral carcinoma
|
Cx43 correlates as a prognostic biomarker
|
[130]
|
|
Cx43
|
HBV hepatocellular carcinoma
|
Cx43 expression correlates with early tumor recurrence and survival
|
[133]
|
|
Cx43
|
Ras-transformed NIH-3 T3 cell
|
Cx43 5′ UTP active in transformed cell and 3′ UTP active in normal cell
|
[72]
|
|
Cx32
|
Prostate
|
Increased by Vit.D3 and sensitizes cells to growth inhibition by Vit.D3
|
[63]
|
|
Cx32
|
Pancreatic and prostate cancer
|
Cx32 C-terminus required for growth and stability of gap junctions
|
[68]
|
|
Cx37
|
Gastric tumors
|
Cx37 siRNA negatively correlated with cancer development and promotes apoptosis
|
[124]
|
|
Cx26
|
Cervical cancer-HeLa
|
Redistribute cAMP and blocks cell cycle progression
|
[69]
|
|
Cx46 & Cx43
|
Glioblastoma cancer stem cell
|
Cx46, not Cx43 is detected; During differentiation, Cx46 reduced and Cx43 increased
|
[126]
|
|
Cx30 & Cx43
|
Breast
|
Cx30 deletion and mutation in human tumors; Cx30/Cx43 as potential prognostic markers
|
[128]
|
