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Table 2 Reported phosphorylation sites of connexins, responsible kinases and the effect on hemichannels

From: Regulation of gap junction channels and hemichannels by phosphorylation and redox changes: a revision

Kinases

Connexins

Phosphorylated residues

Reported effects on HCs

References

PKA

Cx35/36

n/a

reduced HC permeability

[89, 90]

AKT (PKB)

Cx43

Ser369, Ser373

increased HC permeability

[85, 88]

Cx26

n/a

increased HC permeability

[92]

PKC

Cx43

Ser368

reduced HC permeability

[47, 83, 84, 86, 93]

MAPK

Cx43

serines 255, 262, 279, 282

reduced HC permeability

[54, 74, 87]

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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