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Fig. 7 | BMC Cell Biology

Fig. 7

From: Matrix metalloproteinase 9 induces endothelial-mesenchymal transition via Notch activation in human kidney glomerular endothelial cells

Fig. 7

The γ-secretase inhibitor GSI-I regulates protein expression in rMMP-9-induced EndoMT. a Western blot analysis of α-SMA, NICD, Notch-1, CD31 and VE-cadherin expression in rMMP-9-induced EndoMT in the presence or absence of GSI-I six days after treatment. β-actin was used as a loading control. b Statistical analysis of protein expression in rMMP-9-induced EndoMT in the presence or absence of GSI-I. c Morphological changes in HKGECs induced by TGF-β1 (10 ng/ml) or rMMP-9 in the presence or absence of GSI. Data are expressed as mean ± SEM with n ≥ 3 for each experimental group, *P < 0.05

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