Fig. 2
From: Early changes in the metabolic profile of activated CD8+ T cells
Stimulation of CD8+ T cells with tetramers leads to enhanced glycolysis with no significant change in the citric acid cycle. Purified CD8+ T cells were treated with soluble CD3/CD8 mAbs or OT-I tetramers for the indicated time periods. Samples were analyzed by MS coupled high-performance anion-exchange chromatography for intermediates of glycolysis – Fructose-1,6-bisphosphate (F-1,6-bp), 3-phosphoglycerate (3-PG) and pyruvate (a) and the citric acid cycle – a-ketoglutarate, malate and fumarate (b). n = 5