Skip to main content

Table 4 Relative expression of mRNA of nesprin-1 isoforms and markers of differentiation in normal human skeletal muscle

From: Specific localization of nesprin-1-α2, the short isoform of nesprin-1 with a KASH domain, in developing, fetal and regenerating muscle, using a new monoclonal antibody

  Fetal Skeletal Muscle Adult Skeletal Muscle
  Fetal 1 Fetal 2 Fetal 3 Adult 1 (30y) Adult 2 (18y) Adult 3 (67y) Adult 4 (85y) Adult 5
N1-Giant 269.0 ± 127.7 (8) 290.3 ± 36.6 (4) 5.3 ± 3.3 (5) 172.4 ± 27 (5) 113.6 ± 16.5 (4) 119.2 ± 30.4 (6) 47.5 ± 9.3 (5) 86.8 ± 25.9 (3)
N1-β1 2.4 ± 1.9 (5) 1 (2) <1 (2) 21.3 ± 2.9 (4) <1 (2) <1 (2) 8.2 ± 3.0 (2) 9.8 ± 2.6 (3)
N1-β2 8.0 ± 1.9 (4) 124.4 ± 43.2 (8) <1 (3) 4.9 ± 1.7 (4) <1 (2) 1 (2) <1 (3) 1 (2)
N1-α1 nd (1) nd (1) nd (1) nd (1) nd (1) nd (1) nd (1) nd (1)
N1-α2 120.8 ± 33.9 (4) 66.2 ± 18.1 (5) 10.3 ± 2.3 (5) 17.8 ± 5.8 (4) 48.6 ± 12.7 (6) 140.3 ± 25.4 (5) 30.1 ± 5.3 (5) 55.4 ± 18.2 (3)
CKM 4237 ± 95 (4) 1611 ± 295 (4) 3404 ± 971 (5) 33117 ± 2320 (3) 89214 ± 10651 (4) 117928 ± 25917 (4) 20372 ± 1290 (4) 19033 ± 1851 (4)
Desmin 11928 ± 802 (3) 3260 ± 1034 (6) 14542 ± 3431 (5) 38904 ± 1567 (3) 84550 ± 20608 (4) 82022 ± 23108 (5) 37307 ± 617 (5) 27197 ± 4613 (4)
  1. Results expressed as: Mean ± SD (n). “n” = number of repeat measurements. nd = Not detected