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Fig. 3 | BMC Cell Biology

Fig. 3

From: Intermittent hypoxia causes NOX2-dependent remodeling of atrial connexins

Fig. 3

The abundance and distribution of Cx43 and of N-cadherin immunoreactive staining are not altered in ventricles of mice exposed to intermittent hypoxia. Cx43 and N-cadherin were localized by double label immunofluorescence in frozen sections of ventricles from wild type C57BL/6 J mice treated with RA or IH. a Representative photomicrographs show localization of Cx43 (red) or N-cadherin (green) and their co-localization (white). Bar, 20 μm. Cx43 and N-cadherin are detected in both RA and IH samples; levels of each, their distributions, and their overlap do not appear very different between RA and IH. b Graph depicts the quantitation of the abundance of Cx43- and N-cadherin-immunoreactivity in these ventricular samples. The abundances of Cx43 and N-cadherin did not differ significantly between RA (black bars) and IH treated mice (grey bars; p >0.05, Student’s t test). c Graph depicts the quantitation of the sizes of ventricular Cx43- and N-cadherin-containing immunoreactive objects in these samples. The sizes of Cx43 or N-cadherin immunoreactive particles did not differ significantly between RA (black bars) and IH treated mice (grey bars; p >0.05, Student’s t test). n = 5 for RA, n = 3 for IH

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