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Table 3 Residues and domains implicated in the stability and the oligomerization of connexins for cardiac Cx40, Cx43 and Cx45 expressed in myocytes

From: Cardiac Cx43, Cx40 and Cx45 co-assembling: involvement of connexins epitopes in formation of hemichannels and Gap junction channels

  Connexins Oligomerization of connexins
Stability of connexins Assembly signal Selectivity signal
Domain Motif Domain Motif Domain Motif
Cx40 E2
M3
(cytoplasmic end)
Assumed similar to Cx43
LLNTY
M3 LN [38] n.d. : assumed similar to Cx43
Cx43 E2
M3
(cytoplasmic end)
YGF [5, 31, 36]
LLRTY [37, 38]
M3 151-LR-154 [37] NTH
(position 11,12)
M3
DK [37, 39, 45]
LR
Cx45 E2
M3
(cytoplasmic end)
Assumed similar to Cx43
LLKTY
n.d. : assumed similar to Cx43: LK n.d. : assumed similar to Cx43
  1. In bold and underlined are specific residues implicated in the fine regulation (see text for more details). For Cx40 and Cx45 a similar function of motifs not identified yet is assumed (e.g. YGF in E2 of Cx43 implicated in the stability of connexins). n.d.: not determined