Cardiac Cx43, Cx40 and Cx45 co-assembling: involvement of connexins epitopes in formation of hemichannels and Gap junction channels

Table 3 Residues and domains implicated in the stability and the oligomerization of connexins for cardiac Cx40, Cx43 and Cx45 expressed in myocytes

	Connexins		Oligomerization of connexins
	Stability of connexins		Assembly signal		Selectivity signal
	Domain	Motif	Domain	Motif	Domain	Motif
Cx40	E2 M3 (cytoplasmic end)	Assumed similar to Cx43 LLNTY	M3	LN [38]	n.d. : assumed similar to Cx43
Cx43	E2 M3 (cytoplasmic end)	YGF [5, 31, 36] LLRTY [37, 38]	M3	151-LR-154 [37]	NTH (position 11,12) M3	DK [37, 39, 45] LR
Cx45	E2 M3 (cytoplasmic end)	Assumed similar to Cx43 LLKTY	n.d. : assumed similar to Cx43: LK		n.d. : assumed similar to Cx43

In bold and underlined are specific residues implicated in the fine regulation (see text for more details). For Cx40 and Cx45 a similar function of motifs not identified yet is assumed (e.g. YGF in E2 of Cx43 implicated in the stability of connexins). n.d.: not determined

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