Cardiac Cx43, Cx40 and Cx45 co-assembling: involvement of connexins epitopes in formation of hemichannels and Gap junction channels

Table 4 Residues and domains implicated in the stability and the docking of hemichannels for cardiac Cx40, Cx43 and Cx45 expressed in myocytes

	Stability and docking of hemichannels
	Domains	Motifs
Cx40	NTH E1 E2	Similar to the motifs ensuring the stability of connexins ExxxE [62–64] DxQI 53-CxxxxxxCxxC-66 (mCx40) VxxxxxxxHPxN 184-CxxxxxxCxxxC-197 (mCx40)
Cx43	NTH E1 E2	Similar motifs to the motifs ensuring the stability of connexins KxxxK [62–64] NxLQ 53-CxxxxxxCxxC-65 (mCx43) TxxxxxxxHQxD 186-CxxxxxxCxxxC-199 (mCx43)
Cx45	NTH E1 E2	Similar motifs to the motifs ensuring the stability of connexins RxxxE [65] NxLQ 52-CxxxxxxCxxC-63 (mCx45) VxxxxxxxHKxD 208-CxxxxxxCxxxC-221 (mCx45)

In bold and underlined are specific residues implicated in the fine regulation of the formation of GJCs (see text for more details). n.d.: not determined

ISSN: 2661-8850