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Fig. 1 | BMC Cell Biology

Fig. 1

From: Pannexin channel and connexin hemichannel expression in vascular function and inflammation

Fig. 1

Diagram of mouse Pannexin 1 membrane topology and post-translational modifications. Based on sequence analysis using the UniProt database, Pannexin 1 is predicted to contain four transmembrane regions. It contains four conserved extracellular cysteine residues (blue) in the extracellular loops and a confirmed N-glycosylation site (green) necessary for plasma membrane translocation. Multiple post-translational modification sites by S-Nitrosylation (pink), phosphorylation (yellow), or proteolytic caspase cleavage (gray) have been confirmed to regulate channel gating. Additional post-translational modifications were predicted and annotated using PhosphoSitePlus (orange)

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